Your professional resource for information on the rational use of hormone therapy to manage the symptoms of menopause.

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Welcome to How, When, & WHI: Guidance on Menopause Management, your professional resource for information on the rational use of hormone therapy to manage the symptoms of menopause.

Our faculty advisors are preeminent experts in women’s health and provide their expert perspectives on complex issues such as cardiovascular risk associated with hormone therapy and whether vaginal estrogen therapy is local or systemic. The appropriate use of hormone therapy will be demonstrated using complex patient case studies in a certified Webcast. The key outcomes data, including time since menopause and age-stratified results, from the WHI are summarized concisely to address common misconceptions and support an evidenced-based approach to caring for menopausal women. Tools, resources, and infographics that support clinical decision-making are available. And finally, learn and compete with your colleagues, and have fun with How, When, & WHI Trivia. Come back often as new resources will continue to be added.

Expert Perspectives

Renowned faculty in women’s health provide their expert perspectives on key concerns related to management of menopausal symptoms with hormone therapy. Dr. Diane Pace provides her perspective on the history of hormone therapy leading up to the WHI trial, the effects of the early termination of the study, and the implications of the results and questions related to hormone therapy that remain unanswered. Dr. James Simon provides his perspective on whether vaginal estrogen therapy is systemic or local, describes the evidence on local estrogen therapy in breast cancer survivors, and illustrates variations in hormone absorption by dose, location, and medication. Dr. Lisa Larkin gives her perspective on the cardiovascular risk data from the most recent stratified analyses of age and time since menopause in the WHI and describes how to translate these data into rational use of hormone therapy for menopausal women. 

Overview of the Women’s Health Initiative


Is Vaginal Therapy Systemic or Local?


The Women’s Health Initiative and Cardiovascular Disease


Hormone Therapy for Menopause Management: Context, Clarity, and Clinical Application of the WHI

This certified activity will include an overview of the combined intervention plus postintervention outcomes from the Women’s Health Initiative, including stratified analyses by age and time since menopause. Then, the expert faculty will present complicated cases of women who present with the symptoms of menopause and will provide instruction on care based on these data and clinical practice guidelines. The faculty will highlight key clinical concerns such as genitourinary symptoms in a young, healthy woman, vasomotor symptoms despite nonhormonal therapies in a woman with a history of cardiovascular disease, and the decision-making process for extended hormone therapy vs tapering in a postmenopausal woman.

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Faculty Bios and Disclosures


Associate Professor,
The University of Tennessee Health Science Center/Memphis College of Nursing
Memphis, Tennessee

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Lisa Larkin, MD, FACP, NCMP, IF

Lisa Larkin, MD, & Associates
Cincinnati, Ohio

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James Simon, MD, CCD, NCMP, IF, FACOG

Clinical Professor of Obstetrics and Gynecology,
The George Washington University
Washington, DC

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This educational initiative is supported by an educational grant from Pfizer Inc.

Forefront Collaborative is an ACCME-accredited independent healthcare education company that engages, unites, and supports the best minds in healthcare in the pursuit of moving patient care forward.